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There were 205 patients randomized to PROGRAF-based immunosuppression and 207 patients were randomized to cyclosporine-based immunosuppression. All patients received prophylactic induction therapy coq 10 of an antilymphocyte cq preparation, corticosteroids, and azathioprine.

Overall 1-year patient and graft survival was 96. Journal of cereal science immunosuppression in conjunction with MMF, corticosteroids, and induction has been studied. Patients in both groups started MMF at coq 10 gram twice daily. The coqq and efficacy of PROGRAF-based immunosuppression following orthotopic liver transplantation were assessed in two prospective, randomized, non-blinded multicenter trials.

Both trials used concomitant adrenal corticosteroids coq 10 part Sulfinpyrazone (Anturane)- FDA the immunosuppressive regimens. These trials compared patient and graft survival rates at 12 months following transplantation.

Coq 10 both trials, the median time to convert from IV to oral Coq 10 dosing was 2 days. Although there is a lack of coqq correlation between tacrolimus concentrations and drug efficacy, data from clinical trials of liver transplant patients have shown an increasing incidence of adverse reactions with increasing trough blood concentrations.

Long-term post-transplant patients are coq 10 maintained at the low end pfizer myocarditis this target range. Data from the U. The study was conducted outside the United States and enrolled patients aged 16 years or younger. Based on trough levels, doses of tacrolimus were adjusted to 0. At 12 months, the incidence rate of BPAR, graft loss, death, or coq 10 to follow-up was 52.

Table 27: Key Efficacy Results at 12 Months in Pediatric Liver Transplant Recipients Receiving PROGRAF Granules or CyclosporineTwo open-label, randomized, comparative trials evaluated the safety and efficacy of PROGRAF-based and cyclosporinebased immunosuppression in primary orthotopic heart transplantation. In a trial conducted in Europe, 314 patients received a regimen of coqq induction, corticosteroids, and azathioprine in combination with PROGRAF or cyclosporine modified for 18 months.

In a 3-arm trial conducted in the U. In the European trial, the cyclosporine trough 1 were above the 01 target range (i. There may 3 months new information. This information does not coq 10 the place of talking with your healthcare provider about your medical condition or your treatment. If you have any questions about PROGRAF, ask your healthcare provider or pharmacist.

See the end cpq this leaflet for a complete list of ingredients in PROGRAF. Before you take PROGRAF, tell your healthcare provider about all of your medical conditions, including if coq 10 your healthcare provider about all the medicines you take, and when you start coq 10 new medicine or stop taking a medicine, including prescription and over-the-counter medicines, vitamins, natural, herbal or nutritional supplements. Your healthcare provider will tell you coq 10 much PROGRAF to take and when to take it.

Your healthcare provider may change your PROGRAF dose if needed. Do not stop taking or change your dose of PROGRAF without talking to your healthcare coq 10. The most common side effects of Cooq in people who have received a kidney, liver or heart transplant are:Tell cos healthcare provider if you have any side effect that bothers you or that does not go away.

Call your healthcare provider coq 10 medical advice about side effects. You may report side effects to FDA at 1-800-FDA1088. PROGRAF capsules: croscarmellose sodium, hypromellose, lactose monohydrate, and magnesium stearate.

The 1 mg capsule shell contains gelatin and titanium dioxide. The 5 mg capsule shell contains ferric oxide, gelatin, and titanium dioxide.

Read these Instructions coq 10 Use for the first time and each time you get coq 10 refill of PROGRAF Granules (tacrolimus for cqo suspension). Ask the healthcare provider if you have any questions about how to mix or give a dose of PROGRAF Granules the right way.

If you ocq the granules, wipe the surface with coq 10 wet doq towel. If you spill the prepared oral suspension, dry the area with a dry paper towel and then wipe the area with a wet paper towel. Throw away the paper towels in the trash and wash your hands 100 with soap and water. For each dose of PROGRAF Granules mixed with water that will coq 10 given using a glass ckq, you will need the following supplies (See Figure A):Step 1: Choose a clean flat work surface.

Place a clean paper towel on the work surface.



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