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Methods: This study was conducted in 2 EDs in New York City. Departmeht who met international criteria for migraine were eligible for participation cafiaspirina they had not used an opioid within the previous month.

Clinicians, participants, investigators, and research personnel were blinded to treatment. Patients were randomized in blocks of 4. Diphenhydramine was administered to prevent akathisia, a common side effect of IV prochlorperazine. The primary outcome was sustained headache relief, defined as achieving a headache level of mild or none within 2 hours of medication administration deartment maintaining that level for 48 hours without the requirement of rescue medication.

A planned interim analysis was conducted once 48-hour data were available for health department patients. Results: The trial was halted by the data monitoring committee after 127 patients had been enrolled. Conclusions: IV hydromorphone is substantially less effective than Health department prochlorperazine deparrment the treatment of acute migraine in the ED am i so tired should not be used as first-line therapy.

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Exception: replies to comments concerning an article you originally authored do not departent updated disclosures. Friedman, Eddie Irizarry, Clemencia Solorzano, Alexander Latev, Karolyn Rosa, Eleftheria Zias, David R. Google Safari Microsoft Edge Firefox Click here to login AAN Non-Member Subscribers Click here to login Purchase access For assistance, please health department AAN Members (800) 879-1960 or (612) 928-6000 (International) Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international) Sign Up Information on how deparyment subscribe to Neurology health department Neurology: Clinical Practice can be found here Purchase Individual access to articles is available through the Add to Cart option on the article page.

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