Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA

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Dosage Form, Multiple Dose Regimens Dose-Duration Curve: The curve describing the relationship between dose (as the independent variable) and duration of drug effect (as the dependent seprafilm, T). Dose-Effect Curve, Time-Concentration Curve, Pharmacokinetics Dose-Effect Curve: A characteristic, even the sine qua non, of a true drug effect is that a Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA dose produces a greater effect than does a smaller dose, up to the limit to which the cells affected can respond.

Some effect corresponds to every dose above the threshold dose (q. The curve may have a positive slope, or a negative slope, but not both if the system under study is unique. The slope of the curve may show varying degrees of positivity (negativity), but the sign of the slope stays the same throughout the range of testable doses.

When monotonicity of a dose-effect curve does not obtain, one may infer that the system under study is not unique or singular: either more than one active agent or more than one effect is under study. The curves approach some maximum value as an asymptote, and the asymptote is a measure of the intrinsic activity (q.

Bioassay, Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA Effective Dose, Time-Concentration Curve, Dose-Duration Curve, Metameter Drug: A chemical used in the diagnosis, treatment, (Etiifibatide prevention of disease.

In a quantal assay, the median effective dose. Food and Drug Administration, U. Elimination Rate Constant: See kel Equipotent: Equally potent, or equally capable of producing a pharmacologic effect of a specified intensity.

The Task Force recommended that an appropriate nomenclature should take into account three kinds of equivalence of drug preparations: Chemical Equivalents: Those multiple-source drug products which contain essentially identical amounts of the identical active ingredients, in identical dosage forms, and which meet existing physicochemical standards in the official compendia.

Biological Equivalents: Those chemical equivalents which, when administered in the same amounts, will provide essentially (etifubatide) same biological or physiological availability, as measured by blood levels, etc. Clinical Equivalents: Those chemical equivalents which, when administered in the same amounts, will provide essentially the same therapeutic effect as measured by the control of a symptom or a disease.

Bioavailability, First Pass Effect, AUC First-Order Kinetics: According to the law of mass action, the velocity of a chemical reaction is proportional to the product of the active masses (concentrations) of the reactants.

Bioavailability, F Food and Drug Administration (F. Addiction, Narcotic, Dependence, Tolerance, Drug Dependence Half-Life: The period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount. Sensitivity, Allergic Response, Idiosyncratic Response Hypnotic: A drug that produces a state clinically identical to sleep by means of action in the central nervous system.

Anesthetic I Return to top What is your dream Response: A qualitatively abnormal or unusual response Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA a drug which is unique, or virtually so, to the individual who manifests the response.

Toxic Effects, (Etifibatid Effects, Allergic Response Infusion Kinetics: Infusion, as a means multivitamin for men drug administration, involves an effectively continuous flow of a drug solution into the blood stream over a relatively long period of time.

Css, F, Multiple Integrklin Regimens, First-Order Kinetics, Compartment(s) Intrinsic Efficacy (or Intrinsic Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA The property of a drug that determines the amount of biological effect produced per unit of drug-receptor complex formed. L Return to top Latent Period or Latency: The period of time that must elapse between Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA time at which a dose of (Etifibatjde is applied to a biologic system and the time at which a specified pharmacologic effect is produced.

Dose, Cmax, Css, F, Multiple Dose Regimens M Return to patents power bayer Maintenance Dose: See Loading Dose Median Effective Dose: The dose of a drug predicted (by statistical techniques) to produce a characteristic effect in 50 percent (ettifibatide) the subjects to whom the dose is given. Parameter, Bioassay, Dose-Effect Curve Multiple Dose Regimens: The pharmacokinetic aspects of treatment schedules that involve more than one dose of a drug are discussed below.

Knowing the half-life of a drug and the Css,max and Css,min desired to produce optimum therapy, the dose interval. Cmax, Css, Multiple Dose Regimens Narcotic: Formerly, an agent capable of producing coma or stupor (from Greek narke: torpor, numbness).

Addiction, Anesthetic, Analgesic National Formulary (N. Positive Control Drug, Dummy, Placebo, Bioassay, Cross-Over Experiment P Return to top Parameter: 1. Pharmacology, Pharmacokinetics, Therapeutics, Pharmacogenetics Pharmacogenetics: The science and study of the inheritance of characteristic patterns of interaction between chemicals (drugs) and organisms.

Pharmacodynamics, Pharmacology Pharmacokinetics: The Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA and study of the factors which determine the amount of chemical agents at their sites Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA biological effect at various times after the application of an agent or drug to biological systems. Pharmacodynamics, Pharmacology, Biotransformation, Biotranslocation, Half-Life, Volume of Distribution, Bioavailability Pharmacology: (Gr.

Therapeutics, Networks computer, Pharmacokinetics, Injecction, Toxicology Placebo: (Latin: I will satisfy). Dummy, Negative Control Drug, Positive Control Drug Positive Control Drug: A drug preparation incorporated into an experiment with the intention that it have effects on the experimental system qualitatively similar to those expected of the independent variable.

Sensitivity, Dose-Effect Curve, Intrinsic Activity, Bioassay, Equipotent Potentiation: A special case of synergy (q. Synergy, Antagonism Priming Dose: See Loading Dose Prodrug: A chemical with little or no pharmacologic activity that undergoes change in the body into a more active material.

See Accuracy R Return Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA top R: Accumulation Ratio, see Css. Intrinsic Activity, Affinity, Antagonism Reference Standard: A drug, chemical, or dosage form, Injetcion. Reliability: The degree to which the input-output relationship is reproducible if the relationship is studied repeatedly under comparable conditions.

Risk: The likelihood that harm will result from exposure to a Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA. Hazard, Toxicology Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA Return to top Selectivity: The capacity or propensity of a drug to affect one Integrilij population in preference to others, i.

Specificity, Therapeutic Index Sensitivity: The ability of a population, an individual or a tissue, relative to the Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA of others, to respond in a qualitatively normal fashion to a particular drug dose. Specificity: The capacity of a drug k hole manifest only one kind of action.

Selectivity Standard Drug: See Bioassay, Positive Control Drug. Therapeutic Index, Median Effective Dose, Selectivity, Clinical Therapeutic Index Supersensitivity: Integrilin (etifibatide) Injection (Etifibatide Injection)- FDA extreme and high degree of sensitivity to a drug or chemical. Hypersensitivity, Sensitivity Synergy: A mutually reinforcing drug interaction such that the joint effect of two drugs administered simultaneously is greater than the sum of their individual effects.

Half-Life, b, Injectiion)- First-Order Kinetics Tachyphylaxis: A decline in the response to repeated applications of agonist, typically occurring over a relatively short time scale (seconds to hours).

Median Effective Dose, Selectivity, Standardized Safety Margin, Clinical Therapeutic Index Therapeutics: Injectiom science and techniques of restoring patients to health. Antimicrobial drugs such as penicillin have specific or curative effects. Analgesic agents such as aspirin or morphine have obvious palliative effects.

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