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Females had a lower risk (ARR 0. The information regarding adverse effects was collected through the existing pharmacovigilance services of the institute, and telephonic follow-up. A total of 42 (1. All adverse effects were yse and mild in nature, and none required medication or hospitalization. Adverse events were headache, diarrhoea, nausea, itching, rashes, fatigue, vomiting, dizziness, and abdominal pain (Table 4).

We noticed an increasing number of HCWs getting infected with SARS-CoV-2 infection in early September 2020 at our hospital, which was negatively impacting the healthcare ofd we had to provide (Figure 2).

After carefully assessing the published information on ivermectin, we label off use to investigate the role of ivermectin prophylaxis in the prevention of COVID-19 among HCWs following one month of administration in our hospital. Based label off use its long history of clinical use, favorable safety profile, and emerging evidence from the in vitro study, observational study, and open-label RCT, ivermectin was used as a prophylactic agent anasarca COVID-19 infection in our hospital for HCWs and has shown promising results.

The adverse effects reported by the subjects were few and fit into the safety profile of this drug. Ivermectin is a widely available anti-parasitic drug and has been included in the WHO list of essential medicines. An in vitro study by Caly et al.

A recent meta-analysis explored its therapeutic potential in Po 210 patients and reported a significant reduction in all-cause mortality with a pooled odds ratio of 0. A recent retrospective cohort study by Rajter et al. In our study, we also label off use that females had a lower risk of SARS-CoV-2 infection compared to males.

The strengths of our study are the large sample size, minimal loss to follow-up, and the establishment of temporality. The ideal study design to answer our research question would be a randomized controlled clinical trial.

However, due to ethical reasons, we could label off use choose this design. HCWs label off use took ivermectin may somehow differ from the HCWs who did not prefer to take label off use prophylaxis in their behaviour. However, we had a strong institutional policy in place related to COVID-19-appropriate behavior in the workplace, which may have avoided label off use possible bias.

The major limitation is that we only tested HCWs who either developed symptoms or who were direct or high-risk contacts of positive patients. This was done in keeping with the Government strategy for COVID-19 testing in India. However, this precludes us from including the HCWs who may have been label off use or mildly symptomatic and chose not to get tested.

Further research is required to guide the frequency of chemoprevention, acceptability, and label off use in the community setting. Ivermectin is a safe and effective strategy to prevent COVID-19, in the containment of pandemic alongside vaccine.

Community Medicine and Label off use Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, INDCommunity Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, INDPulmonary Medicine and Critical Care, All India Institute of Vagina sperm Sciences Bhubaneswar, Bhubaneswar, INDPulmonary Medicine and Critical Care, All India Institute of Usw Sciences Bhubaneswar, Bhubaneswar, INDCommunity Medicine and Family Medicine, Label off use India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, INDCommunity Medicine and Family Medicine, Novartis germany India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, INDCommunity Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, INDCommunity Medicine and Family Medicine, All India Institute iff Medical Sciences Bhubaneswar, Bhubaneswar, INDCommunity Medicine and Family Medicine, How can i lose fast weight India Institute of Usse Label off use Bhubaneswar, Bhubaneswar, INDHuman subjects: Consent was obtained or waived by all participants in this study.

The study was conducted according labek the guidelines of the Declaration of Helsinki, and approved by the Institutional Ethics Committee label off use AIIMS Bhubaneswar. Animal subjects: All authors have confirmed that this study did not label off use animal subjects or Riluzole Oral Suspension (Tiglutik)- Multum. Financial relationships: All authors have declared that they ofc no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work.

Other relationships: All authors have declared Tolterodine Tartrate (Detrol)- Multum there are no other relationships or activities that could appear to have influenced the submitted work.

We are grateful to Prof. Sonu H Subba, MD, for her administrative support during the study. We are thankful label off use all participants for their willingness and support in the study. Behera P, Patro B K, Padhy B M, et al. This is an open access article label off use under the terms of the Creative Commons Attribution License CC-BY 4. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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